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Diffusely Abnormal White Matter in Chronic Multiple Sclerosis: Imaging and Histopathologic Analysis Arch Neurol 66:601-609, Seewann,A.,et al, 2009 See this aricle in Pubmed Article Abstract This study classifies DAWM in chronic MS as an abnormality that is different from normal-appearing WM and focal WM lesions, most likely resulting form the cumulative effects of ongoing inflammation and axonal pathology. As such, DAWM is likely to substantially contribute to disease progression and may prove to be an important new disease marker in clinical trials focusing on the neurodegenerative aspects of MS.

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(click to filter results - removes previous filter) clinicoradiologic dissociation disability,neurological MRI MRI,abnormal multiple sclerosis multiple sclerosis,chronic progressive neuropathology white matter disease white matter,dirty-appearing

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